Cancer, Cancer Treatment

A study that was published Tuesday in the Journal of the American Medical Association revealed that vitamin B supplements did not protect people taking them from developing cancer, although past research has suggested it did have the aforementioned effect.

Lead author of the study Dr. Shumin Zhang of Brigham and Women’s Hospital and Harvard Medical School in Boston, along with his team, looked at 5,442 female health-care professionals throughout the United States, all of whom had been taking a supplement including vitamins B6, B12 and B9 (also known as folic acid) daily over a period of about seven and a half years.

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While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism.

They say that “silencing” of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression.

In the January 1, 2009, issue of Cancer Research, a journal of the American Association for Cancer Research, they also report finding a strong link between modification of the key gene, MTHFR, and tobacco use by lung cancer patients - even if the patient had smoked for a short period of time.

WEDNESDAY, Oct. 22 — A new study suggests that people with advanced colon cancer who have a particular gene mutation won’t benefit from the medication cetuximab (Erbitux).

While the drug can add months to the lives of people without a mutation in a gene called K-ras, those who have the mutation won’t see any benefit from this additional therapy, reports the study, which is published in the Oct. 23 issue of the New England Journal of Medicine.

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Signs and Symptoms A lump that appears in the breast that feels at variance with the surrounding breast tissue is typically the first symptom or indication of the presence of breast cancer.
The prestigious Merck Manual has indicated that, in the vast majority of breast cancer cases, it is the woman herself who first discovers the presence of a lump. The first medical indication of breast cancer, as stated in the reviews of the American Cancer Society, is usually discovered when the patient is subjected to a mammogram upon the advice of her doctor. Another indicator of breast cancer is the presence of hardened tissue found in the lymph nodes located under the armpits or in the region of the collarbone. Alterations in the size or shape of the breast, skin dimpling, nipple inversion, or discharge from a nipple may be regarded as alternative indications of the presence of breast cancer. The incidence of pain is not a reliable determinant for the presence of the cancer. Such an observation may in fact be more indicative of other breast related issues such as mastodynia. An appearance that can resemble skin inflammation is caused when breast cancer cells attack the small lymph vessels in the skin of the breast. Such a characterisation is known as inflammatory breast cancer. The onset of pain and swelling, the presence of warmth and redness all across the breast, together with a skin texture which has the appearance of the outer skin of an orange, are all initial characteristics associated with inflammatory breast cancer. Pagets disease of the breast is yet another, somewhat complex, symptom. This syndrome, which refers to the association of several clinically recognizable features, presents skin changes which are synonymous with eczema, such as redness and mild flaking of the nipple skin. The presence of a tingling sensation, of itching, increased sensitivity, burning, and pain are all characteristics associated with the advance of Pagets syndrome. Another symptom may involve a discharge from the nipple. It has been found that a good proportion of women diagnosed with Paget’s also experienced a lump in the breast. There are times when breast cancer occurs as a metastatic disease. As such, it represents a cancer that has spread beyond the original source and into neighbouring areas. This type of breast cancer will give rise to symptoms that depend on where the metastasis is situated. The bone, liver, lung and brain are where Metastasis is most commonly found. An occult breast cancer can sometimes manifest itself in the form of unexplained weight loss. Another symptom could present itself in the form of fevers or chills. Further determinants of metastatic breast cancer can take the form of bone or joint pains, as well as jaundice or possibly even neurological indications. It must be remembered that some of these symptoms are non specific, and as such may be applicable to many other illnesses. In this respect, therefore, it has been found that many symptoms of breast disorder do not actually turn out to represent an underlying presence of breast cancer. To establish this notion, benign breast diseases, such as mastitis and fibroadenoma of the breast, are more common causes of breast disorder symptoms. Since there is a distinct possibility of acquiring an underlying breast cancer at almost any age, then the appearance of a new symptom should be taken seriously by both patients and their doctors. Breast Cancer How To Succeed Peter Radford writes Articles with Websites on a wide range of subjects. Breast Cancer Articles cover Background, Classification, Signs and Symptoms, Risk, Prevention, Treatment. Website has many more. View his Website at: breast-cancer-how-to-succeed.com View his Blog at: breast-cancer-how-to-succeed.blogspot.com

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On Wednesday, Avie Products revealed that they would be releasing a new product aimed at fighting against breast cancer, called ?Cue.?

Scheduled to be launched in the United States this month, October being the Breast Cancer Awareness Month, ?Cue? is an electronic waterproof device designed to remind women to regularly examine their breasts, as a means to early detect anything that might be wrong and consequently present themselves to the doctor for a thorough consultation.

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Patients with locally advanced lung cancer who receive chemotherapy and proton therapy, a specialized form a radiation therapy only available in a few centers in the United States, have fewer instances of a serious side effect called bone marrow toxicity than patients who receive chemotherapy and another type of radiation therapy called intensity modulated radiation therapy (IMRT), according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

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- Taking vitamin E and vitamin C supplements may not make cancer less likely, a new study shows.

That finding comes from the Physicians’ Health Study II, which recently showed that taking vitamin C and vitamin E supplements may not lower the risk of heart attack or stroke.

Researchers have now analyzed study data on cancer risk and found no sign of lower cancer risk in people taking vitamin E and vitamin C supplements daily during the study.

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By Michael Kahn

LONDON (Reuters) - British scientists have figured out why some women develop resistance to the most commonly used breast cancer drug, something that raises the risk their tumors will return, according to a study published on Wednesday.

The findings could lead to new tests to determine which women are not likely to benefit from tamoxifen and who should be given other drugs, said Jason Carroll of Cancer Research UK in Cambridge, who led the study published in the journal Nature.

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A protein known to inhibit the growth of ovarian cancer works in part by forcing cancer cells to eat themselves until they die, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 15 issue of Cancer Research.

The research team also found that expression of the protein, known as PEA-15, is an independent indicator of a woman’s prospects for surviving ovarian cancer, said senior author Naoto T. Ueno, M.D., Ph.D. associate professor of breast medical oncology.

Monday October 13, 2008 (foodconsumer.org) — In the National Breast Cancer Awareness Month, we will publish a series of reports on studies and others on the disease to raise readers’ awareness of the fact that breast cancer is a preventable disease.

A study published in the Nov. 2008 issue of British Journal of Nutrition identified a dietary pattern that was linked to increased risk of breast cancer.

The study led by Schulz M and colleagues from German Institute of Human Nutrition in Germany was meant to determine if certain diet pattern is associated with risk of breast cancer.

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