(Ivanhoe Newswire) — Scientists have uncovered a genetic “fingerprint” to help predict whether a patient’s liver cancer will return after treatment.
A team of international researchers studied tissue samples of roughly 300 liver cancer patients to uncover more than 180 genes linked to patient survival. Interestingly, the predictive fingerprint was discovered not in the tumor, but in normal tissue surrounding it.
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By Julie Steenhuysen
CHICAGO (Reuters) - A broad analysis of genes has turned up 26 mutations linked with the most common form of lung cancer, several of which play a role in other cancers as well, researchers said on Wednesday.
The findings, published in the journal Nature, double the number of genes already linked with lung adenocarcinoma, a type of non-small cell lung cancer that accounts for 40 percent of the more than 1 million lung cancer deaths each year.
WEDNESDAY, Oct. 22 — Researchers have identified 26 genes associated with the most common type of lung cancer, adenocarcinoma — more than doubling the number of genes known to play a role in the deadly disease.
The discovery could help in developing individualized ways of diagnosing and treating lung cancer, the top cancer killer, the researchers said.
“Although similar, smaller cancer gene sequencing projects have been reported, our study is the largest to date and provides the statistical power to detect significantly mutated genes,” study co-author Richard Wilson, director of Washington University’s Genome Sequencing Center in St. Louis, said during a Tuesday teleconference.
Scientists at Washington University School of Medicine in St. Louis, United States have identified 26 genes that that are frequently mutated in a common and deadly form of lung cancer, adenocarcinoma. Thus the number of genes known to play a role in the deadly disease has doubled.
“Although similar, smaller cancer gene sequencing projects have been reported, our study is the largest to date and provides the statistical power to detect significantly mutated genes,” study co-author Richard Wilson, director of Washington University’s Genome Sequencing Center in St. Louis, said during a Tuesday teleconference.
- A huge study funded by the National Institutes of Health triples the number of genes linked to lung cancer and points toward new treatments.
The study analyzed DNA sequences from 623 genes in tumor samples from 188 patients with lung adenocarcinoma, the most common form of lung cancer.
The study turned up 26 genes mutated at high frequency in lung cancer tumors. Previously, 10 gene mutations had been linked to lung cancer — and only five of them were known to be mutated at high frequency.