While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism.
They say that “silencing” of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression.
In the January 1, 2009, issue of Cancer Research, a journal of the American Association for Cancer Research, they also report finding a strong link between modification of the key gene, MTHFR, and tobacco use by lung cancer patients - even if the patient had smoked for a short period of time.
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January 13th, 2009 | Posted in Lung Cancer, News | Tags: cancer, crucial, disrupts, functioning, Gene, Genome, Lung, Normal, silencing
WEDNESDAY, Nov. 5 (HealthDay News) — In a genetics first, researchers report that they have decoded the complete DNA sequence of a person with acute myelogenous leukemia.
There were some surprises — eight previously unknown mutations, along with two already identified genetic alterations, were associated with the blood cell cancer.
But more importantly, it is now possible to detect individual genetic differences for each case of cancer, said study senior author Richard K. Wilson, director of the Washington University Genome Sequencing Center, in St. Louis.
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January 4th, 2009 | Posted in Lung Cancer | Tags: cancer, First-Ever, Genome, Mapping, patients